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How much of the coronary calcium seen on CT is real, and how much is image artifact? In this episode of Behind the Science, Adith Arun sits down with Dr. Doosup Shin to discuss their JACC study, "Photon-Counting Detector CT Reduces Calcium Overestimation Compared with Energy-Integrating Detector CT: Micro-CT…
How much cardiovascular risk is hidden in the scans we already perform every day? In this episode of Behind the Science, we explore groundbreaking research on imaging-derived sarcopenic obesity and its relationship to heart failure, cardiovascular death, and overall mortality. The discussion highlights how routine…
In this episode of Behind the Science, Dr. Yogesh Reddy joins to explore how sotatercept improves outcomes in pulmonary arterial hypertension (PAH) and why its effects go beyond traditional vasodilation. Using detailed invasive hemodynamic testing, exercise protocols, and skeletal muscle assessment, the study…
In this episode of Behind the Science, we sit down with Dr Yao to discuss the recent JACC publication, "The Prognostic Value of Serum Interleukin-6 Concentrations for 9 Cardiovascular and Mortality Outcomes: The Cross Cohort Collaboration (CCC)." The discussion explores the growing role of interleukin-6 (IL-6) as a…
In this episode of Behind the Science, Adith Arun is joined by Drs. Rahul Mahajan and Shaan Khurshid to discuss their recent JACC study on using artificial intelligence–enabled electrocardiograms (ECGs) to predict long-term stroke risk. Drawing on data from over 200,000 patients, the team demonstrates how a single…
In this episode of Behind the Science, host Adith Arun sits down with Dr. Evangelos Oikonomou to discuss groundbreaking research published in JACC: "Early Prediction of Heart Failure from Routine Cardiac CT Using Radiomic Phenotyping of Epicardial Fat." Dr. Oikonomou walks us through how AI-powered radiomic analysis…
In this episode of Behind the Science, we explore how coronary artery calcium scoring improves cardiovascular risk assessment in patients with elevated lipoprotein(a). This multicohort study highlights how Lp(a) and CAC serve as independent predictors of ASCVD and how combining both tools enhances risk stratification…
Listen in to JACC's perspective on our newest research, published on June 19 and featuring co-authors Adith Arun, BS, Clyde W. Yancy, MD, MSc. We present readers with another update in our Data Report Series, evaluating trends in excess cardiovascular mortality among Black Americans compared with White Americans from…
Dr. Aaysha Cader, Social Media editor for JACC Interventions and Dr. Chao Gao discuss the pre-specified subgroup analysis of the REC-CAGEFREE I trial: Drug-Coated Balloon Angioplasty vs Drug-Eluting Stents in Noncomplex Coronary Bifurcation Lesions.
Dr. Aaysha Cader, Social Media editor for JACC Interventions and Dr. Antoinette Neylon discuss the randomised KISS trial: Side Branch Additional Treatment for Coronary Bifurcation Lesion Revascularization.
Join us for the latest Behind the Science discussion, featuring an article published in JACC's May 12 focus issue on hypertension. Adith Arun, MD, joins author William B. White, MD, as they discuss a phase 2 randomized trial of the NPR1 agonist XXB750 in patients with resistant hypertension. The interview highlights…
In this interview in JACC's May 12 issue focusing on hypertension, JACC Editor-in-Chief Harlan M. Krumholz, MD, SM, MACC speaks with first author Samantha S. O'Connell, MS, MD, as they discuss a comprehensive global analysis of hypertension trends from 2000 to 2020, drawing on data from nearly 300 population-based…
Can artificial intelligence really adjudicate heart attacks, strokes, and cardiovascular deaths in clinical trials? Adith Arun sits down with Jonathan W. Cunningham to discuss cutting-edge research using AI to automate major adverse cardiovascular event (MACE) adjudication—one of the most expensive and time‑consuming…
At ACC.26, JACC Editor-in-Chief Dr. Harlan Krumholz speaks with Dr. Wayne Batchelor about the ALERT Trial, published in JACC. Their discussion explores how automated EHR-based clinician alerts can help identify patients with significant valvular heart disease who may otherwise be overlooked, improving timely referral…
In a panel at ACC.26, this video features Dr. Clyde Yancy of Northwestern University in conversation with Ambarish Pandey, Lauren Eberly, Jennifer Cluett, and Oluwabunmi Ogugngbe, exploring how social determinants of health can be studied as measurable variables in clinical research. The discussion highlights…
Recorded on the final day of ACC.26, this video features an unscripted conversation between Dr. Ami Bhatt, Chief Innovation Officer at the American College of Cardiology, and Dr. Harlan Krumholz, Editor-in-Chief of JACC. They reflect on the rapid expansion of artificial intelligence in cardiology, discussing its…
Midventricular obstruction in hypertrophic cardiomyopathy (HCM) is rare—but clinically significant. In this episode of Behind the Science, Adith Arun and Alexander Schulz, MD break down new JACC findings showing why midventricular obstructive HCM should be recognized as a distinct, higher‑risk phenotype, rather than…
JACC is pleased to present an interview focusing on two papers presented at CRT. Listen in to JACC Executive Associate Editor Karthik Murugiah, MD, FACC, speak with authors Martin Frydland, MD, PhD, and Helle Søholm, MD, PhD, on their paired DOBERMANN-D and DOBERMANN-T trial research. The trials tested early low-dose…
In this author interview, JACC Associate Editor Seng Chan You, MD, speaks with Bamba Gaye, MD, PhD, about his team's newly published study examining African representation in randomized clinical trials (RCTs) across major general medical and cardiovascular journals from 2019–2024. Listen in to this behind-the-scenes…
In this featured JACC article, author Naveed Sattar, MD, speaks with deputy editor Erica Spatz, MD, MHS, FACC on how to design trials for the increasing field of obesity medicines. Listen in as they discuss a roadmap for next generation cardiometabolic outcome trials in obesity, emphasizing the need to move beyond…
On Behind the Science, host Adith Arun interviews Dr. Rishi Wadhera and Dr. Sanket Dhruva, lead authors of the new JACC Stats Cardiovascular Statistics Report. They discuss why the report was created, what the latest data reveal about hypertension, diabetes, obesity, and cardiometabolic risk, and why younger adults…
In this episode of Behind the Science, Adith Arun sits down with Rishi Shah to uncover the surprising realities behind new JACC data reports on U.S. cardiovascular health. They break down why major gaps in exercise, sleep, medication adherence, and access still persist—despite gains in insurance coverage. Using NHIS…
In this ACHD Guideline Spotlight interview, author Curt J. Daniels, MD, and JACC Consultant Anitra W. Romfh, MD discuss the growing adult congenital heart disease population in the U.S., projected to exceed 2 million by 2050. His viewpoint, published in JACC's February 24 issue, highlights the urgent need for more…
On February 24, JACC's mini spotlight issue brings readers a focused look on the ACHD guideline. This interview with JACC Consultant Yuli Y. Kim, MD, interviewing authors Babar S. Hasan MBBS and Raman Krishna Kumar MD, DM, takes a look at adapting care for patients with ACHD in low to middle income countries. What do…
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