Behind the Science: AI in Cardiovascular Clinical Trials | JACC

Can artificial intelligence really adjudicate heart attacks, strokes, and cardiovascular deaths in clinical trials? Adith Arun sits down with Jonathan W. Cunningham to discuss cutting-edge research using AI to automate major adverse cardiovascular event (MACE) adjudication—one of the most expensive and time‑consuming parts of global clinical trials. They explore how AI models review extensive medical records, assess uncertainty, and work alongside physicians in a hybrid approach that can preserve accuracy while improving efficiency and scalability in large trials.