Designing Next-Gen Cardiometabolic Outcome Trials | JACC

In this featured JACC article, author Naveed Sattar, MD, speaks with deputy editor Erica Spatz, MD, MHS, FACC on how to design trials for the increasing field of obesity medicines. Listen in as they discuss a roadmap for next generation cardiometabolic outcome trials in obesity, emphasizing the need to move beyond traditional MACE focused endpoints toward broader, patient centered outcomes. The interview highlights evolving trial designs, including expanded endpoints, comparisons of placebo versus active controls, and strategies that better reflect real world risk, multimorbidity, and what ultimately matters most to patients.