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GLP-1 (short for glucagon-like peptide-1) medications such as semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro and Zepbound) have transformed the treatment of obesity and type 2 diabetes. These drugs mimic naturally occurring peptide hormones in the body that help regulate appetite, blood sugar, and…
Pancreatic cancer treatment has entered an exciting new chapter. On August 26, 2026, the U.S. Food and Drug Administration (FDA) approved the oral medication daraxonrasib for metastatic pancreatic cancer. This represents a breakthrough in pancreatic cancer treatment. It is the first ever RAS-targeted therapy for…
The American Society of Clinical Oncology, or ASCO, Annual Meeting is the world’s largest oncology conference. The meeting brings together cancer experts, thought leaders and professionals from around the world to present groundbreaking research that is changing patient care and moving the field forward.Drs. Manish…
Thanks to advances in cancer care, more people are living longer after a cancer diagnosis than ever before. People are also being diagnosed at earlier ages, leading to an increased number of cancer survivors worldwide. In this episode of CancerCast, Dr. Manish Shah speaks with Dr. Emily Tonorezos about the growing…
As we age, our blood cells naturally develop mutations. With new sequencing technology, we can now identify very rare and specific mutations in human blood more easily and precisely than ever before. It’s like we now have a path to find the needle in a haystack. Researchers have discovered that some of these…
Lung cancer care is changing rapidly and new advances in surgery and medicine are at the forefront. In this episode of CancerCast, Dr. Manish Shah is joined by two lung cancer experts, Drs. Jonathan Villena and Christine Garcia, to explore how innovations in surgery, biomarker testing, targeted therapy, and…
Bispecific T-cell engager, or BiTE, therapy is an immunotherapy approach that helps the body’s own immune system target cancer cells by bringing immune cells and cancer cells together. In this episode of CancerCast, Dr. Manish Shah is joined by Dr. Mateo Mejia to explain how this form of antibody-based treatment works…
Prostate-specific membrane antigen, or PSMA, is a protein expressed on the surface of prostate cancer cells that has become an important target for both diagnosing and treating the disease. In this episode of CancerCast, Dr. Manish Shah speaks with prostate cancer expert Dr. Scott Tagawa about how this PSMA protein…
Discover how liver cancer treatment is evolving in this episode of CancerCast. Dr. Manish Shah and Dr. Juan Rocca discuss the liver’s complicated and critical role in cancer care, from its position as a hotspot for metastasis to the role of the liver in impacting how well certain immunotherapy, chemotherapy and other…
In this episode of CancerCast, Dr. Manish Shah is joined by Drs. Gail Roboz and Rick Furman, two internationally renowned Weill Cornell leaders in advancing therapies for leukemia and lymphoma, to preview groundbreaking research from the 2025 American Society of Hematology (ASH) Annual Meeting. Drs. Roboz and Furman…
A liquid biopsy is a blood test that looks for cancer cells or genetic material, such as DNA, that are shed into the bloodstream in patients with cancer. In this episode of CancerCast, Dr. Massimo Cristofanilli and Dr. Manish Shah explore how liquid biopsies unlock real-time insights into cancer evolution through…
Mismatch repair deficiency is a condition caused by DNA errors in the body that lead to a high number of mutations, increasing cancer risk. Mismatch repair deficiency is also commonly associated with Lynch syndrome, an inherited genetic syndrome linked to higher rates of many cancers at younger ages, including colon…
Tumor-infiltrating lymphocyte, or TIL, therapy is a new form of cellular immunotherapy that targets cancer cells by leveraging the body’s immune system and specialized cells called T-lymphocytes. This treatment is currently approved by the U.S. Food and Drug Administration (FDA) for metastatic melanoma with additional…
Drs. Manish Shah and Sarah Rutherford explore the groundbreaking research presented at the 2025 ASCO Annual Meeting. They discuss key developments from this year’s meeting, including new immunotherapy and targeted therapy options, the use of circulating tumor cell (ctDNA) and minimal residual disease (MRD) testing…
A familiar voice in a new role. Drs. John Leonard and Manish Shah reflect on the past seven years of cancer care and research as Dr. Leonard passes the microphone over to Dr. Shah as the new host of Weill Cornell Medicine’s CancerCast podcast. They reflect on how far podcasting has come since the launch of CancerCast…
Join Dr. John Leonard for his special annual “Leonard List” episode. He shares his top 10 most interesting lymphoma and blood cancer-related abstracts to be presented at the 2024 American Society of Hematology (ASH) meeting. The ASH annual meeting features the latest and most exciting research in the field from global…
Immunotherapy is a type of cancer treatment that helps your immune system fight cancer. In the last 10 years, immunotherapy has joined the list of standard cancer treatment approaches, alongside chemotherapy, targeted therapy, radiation therapy, and surgery. There are a number of different types of immunotherapies…
The American Society of Clinical Oncology, or ASCO, Annual Meeting is the largest global oncology conference and features state-of-the-art research presentations and cancer care insights from oncology professionals around the world. Every year on the CancerCast podcast, two of Weill Cornell Medicine’s leading experts…
Pathology has a crucial place in the medical field working behind the scenes to ensure patients and their care teams have the most up-to-date information. In cancer care, pathology plays an essential part in not only diagnosing cancer, but also treating and managing it. From examining tissue biopsies to evaluating…
The skeletal system keeps the body upright, but did you know that the bones play a number of pivotal roles in the body? From storing minerals to providing the home for new cell creation, the body’s bones are dynamic and critical to the body in various ways. When things go awry, deterioration, fractures, and pain can…
Pancreatic cancer can be a difficult cancer to diagnose and treat because symptoms don’t often appear until the disease is very advanced. New imaging techniques, personalized therapies and genetic knowledge are helping to change the landscape, as well as enabling families and loved ones to access better screening…
Dr. John Leonard shares his list of the 10 most interesting lymphoma-related abstracts to be presented at the 2023 meeting of the American Society of Hematology (ASH). The ASH annual meeting brings together blood cancer experts from around the world to present the most exciting research in the field. This annual…
The 2023 American Society of Clinical Oncology, or ASCO, Annual Meeting brought together oncologists from around the world to share cutting-edge updates and scientific advancements. Every year, two of Weill Cornell Medicine’s top experts come together to discuss the latest research presented across both solid tumors…
Every child inherits a set of “germline” DNA from each of their biological parents. At times there are also mutations that are passed down. This differs from what are referred to as “somatic” mutations that are only present in cancer cells, but not in every cell in the body. Environmental factors can also contribute…
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