Nov 06, 2026 This Week in Cardiology

The moderate aortic stenosis TAVR trial, blinded withdrawal in the DECISION digoxin trial, CTO-PCI vs no CTO-PCI 10-year results, and the P4 trial are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I PROGRESS Trial

• PROGRESS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607326
• PROGRESS Trial Editorial https://www.nejm.org/doi/full/10.1056/NEJMe2613400
• Genereux Classification https://academic.oup.com/eurheartj/article/38/45/3351/4002776

II Withdrawing Digoxin in the DECISION trial

• DECISION Trial Substudy https://academic.oup.com/eurheartj/article/47/38/5545/8674856
• DECISION Trial - Main Trial https://www.nature.com/articles/s41591-026-04406-6
• Efficacy and Safety of Digitalis Glycosides in HF: Meta-analysis https://jamanetwork.com/journals/jama/fullarticle/2848972
• RADIANCE trial https://www.nejm.org/doi/full/10.1056/NEJM199307013290101
• PROVED trial https://www.jacc.org/doi/10.1016/0735-1097(93)90403-N

III DECISION CTO Trial at 10 Years

• DECISION-CTO Trial 10-Year Outcomes 10.1016/j.jacc.2026.10.068
• DECISION-CTO Main paper https://doi.org/10.1161/CIRCULATIONAHA.118.031313
• EURO-CTO trial https://eurointervention.pcronline.com/article/three-year-outcomes-of-eurocto-a-randomized-multicentre-trial-comparing-revascularization-and-optimal-medical-therapy-for-chronic-total-coronary-occlusions
• COMET-CTO trial https://pmc.ncbi.nlm.nih.gov/articles/PMC9868942/
• EXPLORE Trial https://www.ahajournals.org/doi/10.1161/JAHA.123.033556
• ORBITA-CTO trial https://www.jacc.org/doi/10.1016/j.jacc.2026.03.027

IV The P4 Trial

Coronary CT Angiography Cuts Procedural Time Relative to IVUS-Guided PCI https://www.medscape.com/viewarticle/coronary-ct-angiography-cuts-procedural-time-relative-ivus-2026a1001684

• P4 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2610771

The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

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