Investigating markers of Alzheimer’s in individuals with Down syndrome

Adults with Down syndrome have a greatly increased risk of developing Alzheimer's disease later in life. Ongoing research focuses on investigating different markers of Alzheimer's disease in adults with Down Syndrome. These studies are specifically examining a neurotransmitter system called the cholinergic system that is vitally important for cognition and known to decline early in Alzheimer's disease in the neurotypical population. Understanding the progression of these different markers associated with Alzheimer's disease will provide essential data for future therapeutic trials in adults with Down Syndrome.

Center for Cognitive Medicine website: https://www.vumc.org/ccm/welcome

Trial Ready Cohort for Down Syndrome: https://www.vumc.org/ccm/trcds

Featuring: Jason Russell, Ph.D., Postdoctoral Research Fellow in Psychiatry

Interviewer: Paul Newhouse, M.D., Jim Turner Professor of Cognitive Disorders; Professor of Psychiatry & Behavioral Sciences, Pharmacology, and Medicine; Director, Vanderbilt Center for Cognitive Medicine; VKC Member