Justin Long and John Hodgman reunite to say there's only one Ozempic

Jan 21, 2026

47:11

Diabetes Type 2 Weight Management Diabetes Type 1

Episode Description

You’ll recall that actors Justin Long and John Hodgman achieved advertising fame in the latter part of the 2000s for their participation in Apple’s long-running Get a Mac campaign.

Now, the pair have reunited for Novo Nordisk’s There’s Only One Ozempic campaign, which debuted Tuesday morning.

In the spots, Long represents Ozempic and its FDA-approved indications, while Hodgman represents “other GLP-1s for type 2 diabetes.”

Novo’s latest consumer-focused brand campaign seeks to differentiate Ozempic from other GLP-1 drugs on the market by underscoring its multiple clinical indications for people living with type 2 diabetes.

As such the pair are featured in a handful of light-hearted ads that take place in front of a water cooler, a whiteboard and on a game show set.

To promote the ad campaign, Long and Hodgman joined managing editor Jack O’Brien for a lively joint interview on this week’s episode of the podcast.

In lieu of our Trends segment, we have some audio bites from editor-at-large Steve Madden’s time on the ground at the J.P. Morgan Healthcare Conference in San Francisco.