#545: Immune Checkpoint Inhibitor Complications: Recognizing and Managing Immune-Related Adverse Events

The Curbsiders Internal Medicine PodcastNov 9 · 1 hr 26 min

Episode Description

Recognize immune checkpoint inhibitor (ICI) toxicities. Learn a practical head-to-toe approach to evaluating new symptoms, managing immune-related adverse events (irAEs), and deciding when it’s safe to rechallenge. Dr. Kerry Reynolds, oncologist at Mass General Brigham Cancer Institute and director of the Severe Immunotherapy Complications Service (SIC), joins The Curbsiders to discuss what every internist should know about irAEs.

Claim CME for this episode at https://ce.vcuhealth.org/curbsiders!

Show Segments

Intro
Why internists need to know about ICI toxicities
How checkpoint inhibitors work
Timing of irAEs
Grading the severity of irAEs
Cases:
- Case 1: ICI colitis
- Case 2: ICI hypophysitis
- Case 3: Triple M overlap syndrome: myositis, myocarditis, and myasthenia gravis-like syndrome
Take-home points
Outro

Credits

Written and produced by: Laura Glick MD
Show Notes: Laura Glick MD
Infographic and Cover Art: Zoya Surani
Hosts: Matthew Watto MD, FACP; Nora Taranto MD, MSCE; Laura Glick MD
Reviewer: Sai S Achi MD, MBA, FACP
Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
Technical Production: PodPaste
Guest: Kerry Reynolds MD

Disclosures

Bristol Myers Squibb - Clinical trial support funds received by my institution – started 6/2022, ongoing; SAGA Diagnostics Advisory Board - started 12/2022, ended 12/2022; CME Outfitters– Educational Speaker Fees – started 9/2022, ended 1/2023; Medscape – Educational Speaker Fees - started 1/2023, ended 1/2023; Regeneron – Advisory Board – started 6/25/2024, ended 9/30/2024; Up to Date – started 12/1/2024; Gilead – Advisory Board – started 5/2025.

Sponsor: Quince

Download the Quince app for app-exclusive offers, or go to Quince.com. Get free shipping on your order and 365-day returns. Now available in Canada and the UK, too. And when Quince asks where you heard about them, let them know it was Curbsiders.

Sponsor: Gusto

Get started at gusto.com/CURB, and get three months free when you run your first payroll.

Sponsor: FIGS

Get 15% OFF your first order at wearfigs.com with code FIGSRX.

Sponsor: Continuing Education Company

CEC has a special offer for Curbsiders listeners: Until December 31st, receive 45% OFF on individual online courses with code CURB45. Visit CMEmeeting.org/curbsiders for details.