Health Podcast Library

What it really takes to bring AI into the hospital room: Avo’s physician-first case for AI-powered clinical decisions

Aug 27, 2026
18:15

Episode Description

Fresh off a Series A, Yair Saperstein, MD, MPH, CEO & Co-founder of Avo, sits down with Logan Plaster to talk about the inflection point his company is at. Dr. Saperstein built Avo from his own experience as a hospitalist overwhelmed by the sheer volume of data, guidelines, and tasks standing between him and the best possible care decision. He walks through how Avo works as an AI intelligence layer inside the EHR, why physician-first design also happens to solve health systems' revenue and compliance problems, and how his thinking on leadership has evolved as Avo grows from a founder-led team to a fifty-person enterprise company. He also shares two analogies – a jazz band and a river of logs – for how he's learned to lead through change.

Yair has been a StartUp Health community member since 2020. If you're building in health innovation, join the community to collaborate with members like Dr. Saperstein and tell your own story.

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