Health Podcast Library

How GPx is turning a smartwatch into an early warning system for heart failure

Aug 7, 2026
14:17

Episode Description

Heart failure patients are often living in a black box – not knowing how they're really doing until they end up in the ER. StartUp Health community member Sean Matsuoka, CEO & Co-founder of General Prognostics (GPx), explains how his team built an algorithm that reads wearable device data alongside a trusted blood biomarker to give doctors an early signal, days before a crisis.

In this Health Moonshot Update, Matsuoka talks with StartUp Health's Logan Plaster about the personal story behind GPx, why device-agnostic design matters, the operational challenge of running a distributed clinical trial, and how the company plans to get reimbursed through existing Medicare and Medicaid codes.

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