Health Podcast Library

Episode #192. What It Takes To Turn Nature-Inspired Molecules Into Real Medicines, with Caitlyn Krebs, Co-founder & CEO of Nalu Bio

Jan 20, 2026
30:23

Episode Description

The endocannabinoid system could become a platform as consequential as GLP-1s, starting with non-addictive, disease-modifying therapies for women’s health and chronic pain.

In this episode, Caitlyn Krebs discusses how generative AI is accelerating the design of oral small molecules that target CB1 and CB2 receptors for pain, inflammation, and endometriosis. She breaks down why today’s endometriosis treatments often force patients into intolerable tradeoffs, how AI helps optimize and prioritize better drug candidates than naturally occurring cannabinoids, and what “preclinical to IND” progress looks like on the path to human studies.

Tune in and learn how AI and the endocannabinoid system could reshape pain care and women’s health from the ground up!


Resources:

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Music by⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠David Cosgrove⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ an accomplished composer, musician, producer, and engineer. Listen to his latest project⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Del Piombo⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.

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