Comparing Marfan Syndrome, Loeys-Dietz Syndrome, and Vascular EDS

Comparing Marfan Syndrome, Loeys-Dietz Syndrome, and Vascular EDS

 

Guest: Juan Bowen, M.D.

Host: Paul Friedman, M.D.

 

Marfan syndrome, Loeys-Dietz syndrome, and vascular Ehlers-Danlos syndrome are clinical problems seen in an aortic clinic. Thoracic aortic aneurysm is a common feature, but the three conditions differ in the severity of aortic and arterial disease and in the types of extracardiac problems that require management. Making an accurate diagnosis is an essential first step in their successful management.

 

Topics Discussed:

• What mutations cause Marfan syndrome, Loeys-Dietz syndrome, and the vascular Ehlers-Danlos syndrome?
• What is the natural history of these three conditions?
• How is aortic and vascular disease managed in these three conditions?
• What are the non-cardiac problems most often encountered in these three conditions?

 

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Podcast episode transcript found here.

 

Recorded on: 17-February-2026