Health Podcast Library
Season 2 • Episode 17

Dr. Farzad Mostashari, Aledade CEO, on why more doctors are going independent

Apr 21, 2026
45:38

Episode Description

This week on Lifers, Christina Farr is joined by Farzad Mostashari, CEO of Aledade and former National Coordinator for Health IT, alongside co-host Mike Desjadon, CEO of Anomaly Health. Farzad traces his journey from CDC to spearheading the nationwide rollout of electronic health records. They discuss why value-based care is the only viable path forward, how AI is finally making it possible to deliver population health insights at scale, and what the current administration is getting right (and wrong) on payment reform. Dive into the Granola notes from this episode: https://notes.granola.ai/t/5a6d9ee2-8592-4471-adec-2d66797d86fd-008umkv4
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Join Christina for an upcoming webinar:

* 5/19 - What will AI do for employer healthcare and benefits with Garner Health - ⁠⁠https://streamyard.com/watch/sQfWpwRzMqWE⁠⁠

* 5/21 - The case for building an AI native electronic health record system - ⁠https://streamyard.com/watch/RCVSNheSPePs⁠

⁠⁠* 6/3 - Privacy, AI & the future of HIPAA with the former founding director of ONC - ⁠⁠https://streamyard.com/watch/bzW4sh8WAPyS⁠⁠

⁠* 6/23 - Not everyone can access the top 1% of physicians. Will AI change that? - ⁠⁠https://streamyard.com/watch/qY9td6fhiXK3⁠⁠

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SPONSOR: Granola
Granola AI, The AI notepad for people in back-to-back meetings: https://granola.ai/lifers with code: LIFERS

Interested in sponsoring the show? lifers@a16zstudios.com

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LINKS:
 Syndromic surveillance piece: https://www.cnbc.com/2020/04/04/syndromic-surveillance-useful-to-track-pandemics-like-covid-19.html 
On the ACCESS MODEL: https://secondopinion.media/p/cms-unveils-major-new-outcomes-based-model-for-tech-enabled-care-what-digital-health-leaders-need-to 

Aledade: https://aledade.com/ 
Anomaly: https://www.findanomaly.com/ 

Chrissy Farr on YouTube: https://www.youtube.com/@LiferswithChristinaFarr 
Chrissy Farr on Instagram: https://www.instagram.com/cfarr/ 
Subscribe to the Second Opinion Newsletter: https://secondopinion.media/ 
Chrissy’s Book: The Storyteller's Advantage: https://www.chrissyfarr.com/books 

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FOLLOW:
Farzad:
https://www.linkedin.com/in/farzad-mostashari-933210 

Mike:
https://www.linkedin.com/in/mike-desjadon-4a0a21a/ 
https://x.com/Mike_Desjadon 

Chrissy:
https://www.linkedin.com/in/christinafarr/ 
https://x.com/chrissyfarr 

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TIMESTAMPS:
(00:00) Intro
(03:01) Disease hunter origins
(04:50) Saving lives at scale
(06:54) EHRs and incentives
(09:22) Advice for AI builders
(10:46) Payment reform bright spots
(14:26) Sponsor: Granola
(15:20) Deflation and CPT shakeup
(17:47) Paying for outcomes
(20:26) Aledade and ACCESS model
(24:23) AI needs value models
(25:58) Electronic health records copilot breakthrough
(28:15) Rural care opportunity
(30:26) Accountability drives adoption
(32:58) Concierge care tradeoffs
(34:43) Scaling primary care capacity
(35:53) Doctors as entrepreneurs
(38:13) Mission and policy moves
(41:02) Rapid fire predictions
(43:51) Bipartisan VBC

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