Health Podcast Library
Season 2Episode 22

Chris Altchek, Cadence CEO, on earning the right to deploy clinical AI

May 26, 2026
49:42

Episode Description

This week on Lifers, Christina Farr sits down with Chris Altchek, who went from investment banking to building Mic, a digital media company that reached 100 million readers, before co-founding Cadence, a health tech company now managing nearly 100,000 chronic disease patients per day. They dig into the hard lessons from media's platform-dependency collapse, what it really takes to build a sustainable business inside the US health system, and why Chris believes AI could make elite-level care accessible to far more Americans within a decade. Dive into the Granola notes from this episode: https://notes.granola.ai/t/02b3e52a-40ef-45e7-bc18-ac35b335e044-009c2hma


Join Christina for an upcoming webinar:
* ⁠5/19 - What will AI do for employer healthcare and benefits with Garner Health - https://streamyard.com/watch/sQfWpwRzMqWE 
* 5/21 - The case for building an AI native electronic health record system - https://streamyard.com/watch/RCVSNheSPePs 
* ⁠⁠6/3 - Privacy, AI & the future of HIPAA with the former founding director of ONC - https://streamyard.com/watch/bzW4sh8WAPyS 
* ⁠⁠6/23 - Not everyone can access the top 1% of physicians. Will AI change that? - https://streamyard.com/watch/qY9td6fhiXK3 


SPONSOR: Granola
Granola AI, The AI notepad for people in back-to-back meetings: https://granola.ai/lifers with code: LIFERS
Interested in sponsoring the show? lifers@a16zstudios.com

LINKS:
Chrissy Farr on YouTube: https://www.youtube.com/@LiferswithChristinaFarr 
Chrissy Farr on Instagram: https://www.instagram.com/cfarr/ 
Subscribe to the Second Opinion Newsletter: https://secondopinion.media/ 
Chrissy’s Book: The Storyteller's Advantage: https://www.chrissyfarr.com/books 


FOLLOW:
Chris:
https://www.linkedin.com/in/chrisaltchek 
https://x.com/caltchek 

Chrissy:
https://www.linkedin.com/in/christinafarr/ 
https://x.com/chrissyfarr 


TIMESTAMPS:
(00:00) Lead In
(00:58) Intro
(02:57) Early life and trading
(05:22) Investor mindset lessons
(09:22) Perseverance as founder
(14:35) Mic Media lessons
(18:53) Sponsor break
(19:46) Cadence origin story
(23:33) Business model and reimbursement
(28:30) Data and remote monitoring
(30:46) Winning health systems trust
(35:16) CMS Access model strategy
(39:25) Cutting inefficiency in care
(42:31) Clinical AI that matters
(45:27) Future of US healthcare
(48:35) Wrap

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