PREVENT in East Asia: Can One Risk Score Fit All? | JACC Baran

Hosts Mitsuaki Sawano, MD, and Satoshi Shoji, MD welcome Prof. Kosuke Inoue (Kyoto University) and Dr. Yuichiro Mori (Kyoto University) to discuss their JACC Brief Report, “Evaluation of the PREVENT Equations in a Nationwide Cohort of 7.7 Million Korean Adults.” Using one of the world’s largest national health databases, the study externally validates the AHA-developed PREVENT risk equations in an East Asian population, showing good discrimination and calibration for ASCVD, outperforming the traditional Pooled Cohort Equations, while highlighting persistent overestimation of heart failure risk, particularly in men. This episode explores why risk prediction models often behave differently across regions, what PREVENT gets right in East Asia, where recalibration may still be needed, and how global collaboration is reshaping cardiovascular risk assessment.