ESC Day 4 – JACC SimPub Spotlight | JACC Baran

Mitsuaki Sawano, MD, with Nobuhiro Ikemura, MD highlight two JACC papers simultaneously published at ESC 2025. “Comparison of Extended Cryoballoon Ablation, Standard Cryoballoon Ablation, and Radiofrequency Catheter Ablation in Patients with Persistent AF (EXCAPE-AF Trial)” – In persistent AF, extended CB with posterior wall isolation offered no benefit over standard CB or RF, underscoring PVI as central. 2nd paper titled “Impact of Obicetrapib on Major Adverse Cardiovascular Events in High-Risk Patients: A Pooled Analysis” – This next-gen CETP inhibitor produced robust lipid lowering and a signal for coronary event reduction, reviving interest after prior CETP concerns.