Cardiac Sarcoidosis Beyond Suppression: Imaging and Biomarkers That Matter | JACC Baran

Hosts Mitsuaki Sawano, MD, and Kentaro Ejiri, MD, welcome Dr. Yusuke Nakashima, MD (Yamaguchi University) and Prof. Shigeki Kobayashi , MD(Yamaguchi University) to discuss their study published in JACC: Cardiovascular Imaging, exploring prognostic markers in patients with cardiac sarcoidosis following steroid therapy. Focusing on a condition in which clinical stability does not always equate to low risk, this episode examines how residual myocardial inflammation on FDG-PET and oxidative stress assessed by urinary 8-OHdG can help stratify future risk of major adverse cardiovascular events after treatment initiation. Through a detailed walk-through of imaging, biomarkers, and longitudinal outcomes, the conversation highlights how combining post-treatment functional imaging with biochemical markers may refine risk assessment, guide follow-up intensity, and move cardiac sarcoidosis management beyond symptom control toward more precise, individualized prognostic evaluation.