Behind the Science | Loss of Y Chromosome & CV Events | JACC

In this episode of Behind the Science, Adith Arun, BS, speaks with Paul Lacaze, PhD, and Sultana Monira Hussain, PhD about their study in JACC's January 6 issue, examining loss of the Y chromosome (LOY) in older men and its association with cardiovascular disease. They discuss the study design, analytical approach, and key findings linking LOY to an increased risk of major adverse cardiovascular events, particularly myocardial infarction. The conversation explores potential biological mechanisms underlying these associations, the strengths and limitations of the data, and how LOY could emerge as a novel biomarker for cardiovascular risk stratification in men. The episode also looks ahead to future research directions and possible clinical applications. #jacc #jaccjournals #behindthescience