Immune Booster 28: Immunometabolism, Inflammation, and Building Biotechs with Luke O'Neill
May 5, 2026
44:56
Episode Description
Luke O'Neill recounts his role in discovering key components of the TLR signaling pathway, explains how pursuing unexpected research questions keeps him motivated, and reflects on his experiences as an entrepreneur founding biotech companies.
Host: Cindy Leifer
Guest: Luke O'Neill
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Links for this episode- MicrobeTV Discord Server
- O'Neill lab
- Identification of MAL in the TLR signaling pathway (Nature, 2001)
- GDF 15, immunometabolism and anti-inflammatories (An Rev Pharmacol Tox, 2026)
- Itaconate and regulation of inflammation (Nat Metab, 2024)
- Time stamps by Jolene Ramsey. Thanks!
Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Information on this podcast should not be construed as medical advice.
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