Naveed Sattar on MACE Benefits From Tirzepatide, Emily Sims on C-Peptide Insights on Glucose During Progression to T1D, and more!

Welcome to the latest episode (October 2026) of Diabetes Care "On Air"—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the October 2026 issue of Diabetes Care and beyond.

4:30 Alice welcomes recurring guest Naveed Sattar, MBChB, PhD, Professor of Cardiometabolic Medicine and Honorary Consultant at the University of Glasgow. His article, "Estimating the True MACE Benefits From Tirzepatide in SURPASS-CVOT Using an Imputed Placebo Analysis of REWIND," is available for free at doi.org/10.2337/dc26-0298.

21:45 Mike is joined by Emily Sims, MD, pediatric endocrinologist at Riley Hospital for Children and a physician scientist in the IU Center for Diabetes and Metabolic Diseases and the Herman B Wells Center for Pediatric Research. She is first author on "C-Peptide Provides Critical Contextual Insight Into Elevated Glucose Values During Progression to Type 1 Diabetes," available for free at doi.org/10.2337/dci26-0022.

36:40 In this month's "Rapid Exchange" segment, Alice and Mike wrap up the episode by reviewing several interesting articles in the October 2026 issue of Diabetes Care. Studies highlighted in this segment include:

• Feodoroff et al. Fracture Risk Is Increased in Type 1 Diabetes and Is the Highest in Individuals With Diabetic Kidney Disease doi.org/10.2337/dc26-0612

• Nielsen et al. Adult Complications of Childhood-Onset Type 1 Diabetes Vary With Age at Diagnosis: A Population-Based Study doi.org/10.2337/dc26-0964

• He, Yu, et al. Early Weight Loss in Impaired Glucose Tolerance Is Associated With Reduced Long-term Mortality and Cardiovascular Risk: The Da Qing Diabetes Prevention Outcome Study doi.org/10.2337/dc26-0689

• Murray Leech, et al. Clinical Utility of a Type 1 Diabetes Genetic Risk Score Measured as Part of MODY Genetic Testing doi.org/10.2337/dc26-1081

• Yin, et al. Gestational Diabetes Mellitus: Recurrence and Future Type 2 Diabetes Risk Across Racial and Ethnic Groups doi.org/10.2337/dc26-0856

• Shah et al. In Utero Exposure to Preexisting or Gestational Diabetes Mellitus Increases Incidence of Diabetes in the Children of First Nations and Non–First Nations Mothers: A Retrospective Cohort Study doi.org/10.2337/dc26-0710

51:30 Mike and Alice share an announcement.

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