Psoriasis Biologics: A Case-Based Guide to Getting It Right

In this episode of Cutaneous Miscellaneous, host Nicholas Brownstone, MD, is joined by Erin Boh, MD, for a case-based discussion on selecting and managing biologics for psoriasis in a rapidly expanding treatment landscape. With more than a dozen biologic and oral options available, treatment selection increasingly requires a balance of clinical evidence, patient factors, and individualized strategy.

Through 3 practical cases, they walk through first-line biologic selection, management of incomplete or waning response, and common pitfalls encountered by residents and early-career dermatologists. A central theme is the role of personalized medicine, including genomic tools like the Mind.Px test, which evaluates gene expression patterns to help identify the most appropriate therapeutic class. The conversation highlights how these tools can reduce trial-and-error prescribing, support payer discussions, and improve patient confidence in treatment decisions.

Tune in to the episode to hear how experienced clinicians integrate clinical judgment with precision testing, navigate real-world complexities, and approach biologic selection with a more personalized, patient-centered framework.