Beyond the Prescription Pad: The Clinical Power of OTC Skin Care

In this episode of Cutaneous Miscellaneous, host Nicholas Brownstone, MD, welcomes Peter Lio, MD, to examine the role of over-the-counter (OTC) skin care in everyday practice.

They discuss evolving perceptions of “drugstore” products, explore what “sensitive skin” may actually represent clinically, and review emerging data on polymer-based cleansing technologies designed to support barrier integrity. The conversation also highlights formulation science, including research evaluating moisturizers that combine hyaluronic acid, natural moisturizing factors, and essential lipids, as well as data suggesting improved quality of life when lightweight adjunctive moisturizers are paired with acne regimens. They also examine clinical findings from a study assessing structured OTC regimens before and after procedures and their impact on tolerability and irritation.

Tune in to the episode for an evidence-informed framework for recommending OTC products with confidence and elevating everyday patient care as a resident or early-career dermatologist.