Chagas Cardiomyopathy — Epidemiology Through Modern Clinical Trials | JACC Baran

Hosts Mitsuaki Sawano, MD, Shun Kohsaka, MD, and Nobuhiro Ikemura, MD welcome Dr. Ryohei Ono, MD, PhD (University of Glasgow / Chiba University) to discuss his simultaneously published JACC study analyzing over 23,000 patients from global HFrEF trials. Once considered regional, Chagas cardiomyopathy is now a global concern. This episode highlights its consistently higher risks of cardiovascular death, heart failure hospitalization, and stroke compared with other etiologies, and explores how etiology should shape prognosis, trial design, and future heart failure care.