Wilson & Moore on B Lymphocytes and eroding islet tolerance in type 1 diabetes, Mittendorfer on the effects of marked weight loss on postprandial glucose disposal in type 2 diabetes, plus "Sweet Talk" with Sir Stephen O'Rahilly

Welcome to the February 2026 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the February 2026 issue of Diabetes.

6:10 To discuss this issue's Paper of the Month, our hosts are joined by authors Christopher Wilson, PhD and Daniel J. Moore, MD, PhD, both of Vanderbilt University. Their article, "B Lymphocytes Impede Tregs to Erode Islet Tolerance in Type 1 Diabetes," is available for free at doi.org/10.2337/db25-0241.

37:05 Next, Darleen speaks with Bettina Mittendorfer, PhD. Dr. Mittendorfer is Senior Associate Dean for Research and Director of NextGen Precision Health, Clinical and Translational Science Unit at the University of Missouri and the lead author of "Effects of Marked Weight Loss Induced by Gastric Bypass Surgery or Low-Calorie Diet Alone on Postprandial Glucose Disposal in Type 2 Diabetes," available for free at doi.org/10.2337/db25-0737.

56:00 In the latest edition of "Sweet Talk," Kevin introduces Sir Stephen O'Rahilly, a clinical scientist at the University of Cambridge and past recipient of the American Diabetes Association's Banting Medal for Scientific Achievement. They discuss O'Rahilly's career, which reshaped scientists' understanding of metabolism and metabolic disease.

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!